What is Gluconolactone (PHA)?
Want smoother, brighter skin but find acids too harsh? Gluconolactone, a polyhydroxy acid (PHA), is the gentle exfoliant made for you. It smooths and brightens like an AHA but also hydrates, so it suits even sensitive and dry skin.
This short guide explains how PHAs work and how to use them.
Quick facts about Gluconolactone (PHA)
| What is it? | A polyhydroxy acid (PHA) and gentle exfoliant |
|---|---|
| What it does | Smooths texture, brightens and hydrates |
| Best for | Sensitive, dry and dull skin, and anyone new to acids |
| Pairs well with | Hyaluronic acid, vitamin C, peptides |
| When to use | Morning or evening, depending on the product |
| Our top pick | Dr Botanicals Hyaluronic Acid 1% & Gluconolactone Mask |
Key benefits at a glance
- Gentle exfoliation for smoother texture
- Brighter, more radiant-looking skin
- Hydrates while it exfoliates
- Suitable for sensitive skin
- Antioxidant properties
- An easy first step into acids
What is gluconolactone?
Gluconolactone is a polyhydroxy acid (PHA). Like other exfoliating acids, it loosens the bonds between dead skin cells so they shed more easily, revealing smoother, brighter skin.
PHA molecules are larger than AHAs like glycolic acid, so they work more slowly and stay at the surface. That makes them much less likely to sting. PHAs are also humectants, meaning they attract water, so skin feels hydrated rather than stripped.
PHA vs. AHA vs. BHA
| PHA (gluconolactone) | AHA (glycolic, lactic) | BHA (salicylic) | |
|---|---|---|---|
| Strength | Gentle | Moderate to strong | Moderate |
| Works | Surface | Surface | Inside pores |
| Hydrating? | Yes | Some | No |
| Best for | Sensitive, dry, dull skin | Dullness, texture | Oily, blemish-prone skin |
How to use gluconolactone
PHA is gentle enough to use in daily creams and serums. Masks are best one to two times a week. Because it is mild, you can usually combine it with vitamin C or peptides in the same routine.
Tip: Any exfoliant makes fresh skin more vulnerable to the sun, so wear SPF 30+ every morning.
Side effects and precautions
PHAs are the gentlest exfoliating acids and rarely cause irritation. If you also use retinol or strong acids, use PHA products on different days at first. Gluconolactone is generally considered suitable during pregnancy. Patch test new products first.
How long until you see results?
| Timeline | What to expect |
|---|---|
| After first use | Smoother, softer skin |
| Week 2–4 | Brighter, more even-looking skin |
| Week 8 | Refined texture and a healthy-looking glow |
Frequently asked questions
Is gluconolactone good for sensitive skin?
Yes. It is the gentlest type of exfoliating acid.
Can I use PHA every day?
In creams and serums, yes. Use masks one to two times a week.
Can I use PHA with retinol?
Many people can, but start on alternate nights to be safe.
Does PHA help with acne?
PHA gently smooths texture; for clogged pores, salicylic acid (BHA) is more targeted.
Is PHA safe in pregnancy?
It is generally considered safe; check with your doctor if unsure.
Shop Gluconolactone (PHA)
- Hyaluronic Acid 1% & Gluconolactone Mask 60ml: Gluconolactone and 1% hyaluronic acid in a smoothing, hydrating mask. Our favorite gentle-exfoliation treat.
- Vitamin C Brightening Orange Mask 50ml: PHA plus vitamin C for a weekly brightening boost that lifts dullness.
- Wrinkle Killer Facial Serum 30ml: PHA works alongside the SYN-AKE peptide and hyaluronic acid for smoother-looking texture and lines.
- Hyaluronic Acid Day Moisturiser 60ml: A daily moisturizer with PHA and hyaluronic acid. Gentle exfoliation you will hardly notice, apart from smoother skin.
- Hyaluronic Acid Day Moisturiser 50ml: Hyaluronic acid and gluconolactone in an everyday cream for dry, dull skin.
- Hyaluronic Acid Mask 50ml: A hydrating mask with PHA to smooth and soften tired skin.
This guide is for general information only and is not medical advice. Always patch test new skincare, and speak to your doctor or dermatologist about any skin concerns.